BLIS M18® (Streptococcus salivarius M18) Evidence & Research

What it is 

BLIS M18® is a naturally occurring oral probiotic strain derived from Streptococcus salivarius, a beneficial bacteria found in healthy mouths. In simple terms, it helps support a balanced oral environment by interacting with bacteria linked to plaque and gum health.

Designed to:

Support oral microbiome balance, plaque control, and gum health markers.

What Research Suggests

A randomized, double-blind, placebo-controlled trial in children showed that 90 days of BLIS® M18 supplementation significantly reduced plaque scores and improved dental health indices compared to placebo.

https://pubmed.ncbi.nlm.nih.gov/23449874/

A clinical study found that short-term supplementation with Streptococcus salivarius M18 reduced Streptococcus mutans counts and improved salivary buffering capacity — an important factor in protecting against acid-producing bacteria.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10373771/

A three-month randomized study reported reductions in gingival bleeding and plaque accumulation following probiotic supplementation, suggesting support for gum health markers.

https://www.mdpi.com/2304-6767/12/7/222

Laboratory and microbiological research shows that S. salivarius strains produce bacteriocins (natural inhibitory substances) that help suppress certain cariogenic bacteria.

https://pubmed.ncbi.nlm.nih.gov/35449617/

What This Means

These studies suggest that BLIS® M18 may help reduce levels of bacteria associated with dental caries and plaque buildup while supporting healthier gum indices. It does not replace brushing or dental care, but it may support a more balanced oral ecosystem when used consistently.

Evena’s Use of BLIS M18®

Evena includes BLIS® M18 to support oral microbial balance overnight — when saliva production naturally decreases and the oral environment becomes more vulnerable to bacterial shifts.

These statements have not been evaluated by the Food and Drug Administration. This information is provided for educational purposes only and is not medical advice.